Shi Rong, Zhao Zhen, Zhou Hui, Zhou Jueyu, Tan Wanlong
Institute of Genetic Engineering, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Department of Urinary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Biomed Rep. 2014 May;2(3):396-403. doi: 10.3892/br.2014.258. Epub 2014 Mar 19.
Bladder cancer is a commom malignancy in the urinary tract that is influenced by genetic and environmental factors. The role of functional polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene with bladder cancer risk remains to be determined. This meta-analysis was performed to derive a more precise estimation of MTHFR Ala222Val and Glu429Ala polymorphisms and bladder cancer risk. Data were collected with the last report up to September 2013. A total of 3,463 cases and 3,927 controls for Ala222Val, and 3,177 cases and 3,502 controls for Glu429Ala were analyzed. The pooled odds ratios (ORs) and 95% confidence interval (CI) were estimated for the association with bladder cancer risk. Overall, no significant associations of Ala222Val and Glu429Ala polymorphisms with bladder cancer risk were found (for Ala222Val: Val/Val vs. Ala/Ala: OR, 1.02; 95% CI: 0.80-1.29; Val/Ala vs. Ala/Ala: OR, 1.02; 95% CI: 0.92-1.12; dominant model: OR, 1.01; 95% CI: 0.87-1.17; recessive model: OR, 1.00; 95% CI: 0.87-1.15; and for Glu429Ala: Ala/Ala vs. Glu/Glu: OR, 1.11; 95% CI: 0.78-1.58; Ala/Glu vs. Glu/Glu: OR, 1.16; 95% CI: 0.95-1.40; dominant model: OR, 1.15; 95% CI: 0.94-1.41; recessive model: OR, 0.96; 95% CI: 0.79-1.15). In stratified analyses by ethnicity, significant associations were observed for Glu429Ala polymorphism in individuals of Middle Eastern descent (Ala/Glu vs. Glu/Glu: OR, 2.11; 95% CI: 1.26-3.53; dominant model: OR, 2.16; 95% CI: 1.16-4.01; recessive model: OR, 1.82; 95% CI: 1.11-3.01). This meta-analysis demonstrated that overall there was no association of MTHFR Ala222Val and Glu429Ala polymorphisms with bladder cancer risk. However, in the stratified analysis by ethnicity the MTHFR Glu429Ala polymorphism was significantly associated with increased bladder cancer risk in individuals of Middle Eastern descent.
膀胱癌是泌尿系统中一种常见的恶性肿瘤，受遗传和环境因素影响。亚甲基四氢叶酸还原酶（MTHFR）基因功能多态性在膀胱癌风险中的作用尚待确定。本荟萃分析旨在更精确地评估MTHFR Ala222Val和Glu429Ala多态性与膀胱癌风险。数据收集截至2013年9月的最新报告。共分析了3463例Ala222Val病例和3927例对照，以及3177例Glu429Ala病例和3502例对照。估计了与膀胱癌风险关联的合并比值比（OR）和95%置信区间（CI）。总体而言，未发现Ala222Val和Glu429Ala多态性与膀胱癌风险有显著关联（对于Ala222Val：Val/Val vs. Ala/Ala：OR，1.02；95%CI：0.80 - 1.29；Val/Ala vs. Ala/Ala：OR，1.02；95%CI：0.92 - 1.12；显性模型：OR，1.01；95%CI：0.87 - 1.17；隐性模型：OR，1.00；95%CI：0.87 - 1.15；对于Glu429Ala：Ala/Ala vs. Glu/Glu：OR，1.11；95%CI：0.78 - 1.58；Ala/Glu vs. Glu/Glu：OR，1.16；95%CI：0.95 - 1.40；显性模型：OR，1.15；95%CI：0.94 - 1.41；隐性模型：OR，0.96；95%CI：0.79 - 1.15）。在按种族分层分析中，观察到中东血统个体的Glu429Ala多态性存在显著关联（Ala/Glu vs. Glu/Glu：OR，2.11；95%CI：1.26 - 3.53；显性模型：OR，2.16；95%CI：1.16 - 4.01；隐性模型：OR，1.82；95%CI：1.11 - 3.01）。本荟萃分析表明，总体而言MTHFR Ala222Val和Glu429Ala多态性与膀胱癌风险无关联。然而，在按种族分层分析中，MTHFR Glu429Ala多态性与中东血统个体膀胱癌风险增加显著相关。
