Notch信号通路在心血管疾病中的作用。
The role of Notch pathway in cardiovascular diseases.
作者信息
Aquila Giorgio, Pannella Micaela, Morelli Marco Bruno, Caliceti Cristiana, Fortini Cinzia, Rizzo Paola, Ferrari Roberto
机构信息
Chair of Cardiology and Laboratory for Technologies of Advanced Therapies (LTTA) Centre, University of Ferrara, Ferrara, Italy.
出版信息
Glob Cardiol Sci Pract. 2013 Dec 30;2013(4):364-71. doi: 10.5339/gscp.2013.44. eCollection 2013.
The recent increase in human lifespan, coupled with unhealthy diets and lifestyles have led to an unprecedented increase in cardiovascular diseases. Even in the presence of a wide range of therapeutic options with variable efficacy, mortality due to heart failure is still high and there is a need to identify new therapeutic targets. Genetic and in vitro studies have implicated the Notch signalling in the development and maintenance of the cardiovascular system through a direct effect on biological functions of vascular cells (endothelial and vascular smooth muscle cells) and cardiomyocytes. Notch signalling is also involved in the modulation of inflammation, which plays a major role in causing and exacerbating cardiovascular diseases. The Notch pathway could represent a new therapeutic target for the treatment of cardiovascular diseases.
近期人类寿命的延长，再加上不健康的饮食和生活方式，导致心血管疾病空前增加。即便存在多种疗效各异的治疗选择，但心力衰竭导致的死亡率仍然很高，因此需要确定新的治疗靶点。遗传学和体外研究表明，Notch信号通过直接影响血管细胞（内皮细胞和血管平滑肌细胞）和心肌细胞的生物学功能，参与心血管系统的发育和维持。Notch信号还参与炎症调节，而炎症在心血管疾病的发生和加重过程中起主要作用。Notch通路可能成为治疗心血管疾病的新靶点。
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