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在以主动脉瓣狭窄为主的成人中采用罗斯手术进行主动脉瓣置换的包埋柱法——15年时主动脉瓣再次手术率为99%。

Inclusion cylinder method for aortic valve replacement utilising the Ross operation in adults with predominant aortic stenosis - 99% freedom from re-operation on the aortic valve at 15 years.

作者信息

Skillington Peter D, Mokhles M Mostafa, Wilson William, Grigg Leeanne, Larobina Marco, O'Keefe Michael, Takkenberg Johanna

机构信息

Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands.

Department of Cardiology Royal Melbourne Hospital, Melbourne, Australia.

出版信息

Glob Cardiol Sci Pract. 2013 Dec 30;2013(4):383-94. doi: 10.5339/gcsp.2013.46. eCollection 2013.

Abstract

BACKGROUND

To report our experience with the Ross operation in patients with predominant aortic stenosis (AS) using an inclusion cylinder (IC) method.

METHODS

Out of 324 adults undergoing a Ross operation, 204 patients of mean age of 41.3 years (limits 16-62) underwent this procedure for either AS or mixed AS and regurgitation (AS/AR) between October, 1992 and February, 2012, implanting the PA with an IC method. Clinical follow up and serial echo data for this group is 97% complete with late mortality follow up 99% complete.

RESULTS

There has been zero (0%) early mortality, and late survival at 15 years is 98% (96%, 100%). Only one re-operation on the aortic valve for progressive aortic regurgitation (AR) has been required with freedom from re-operation on the aortic valve at 15 years being 99% (96%, 100%). The freedom from all re-operations on the aortic and pulmonary valves at 15 years is 97% (94%, 100%). Echo analysis at the most recent study shows that 98% have nil, trivial or mild AR. Aortic root size has remained stable, shown by long-term (15 year) echo follow up.

CONCLUSIONS

In an experience spanning 19 years, the Ross operation used for predominant AS using the IC method described, results in 99% freedom from re-operation on the aortic valve at 15 years, better than any other tissue or mechanical valve. For adults under 65 years without significant co-morbidities who present with predominant AS, the pulmonary autograft inserted with this technique gives excellent results.

摘要

背景

报告我们使用包埋柱(IC)法对以主动脉瓣狭窄(AS)为主的患者进行罗斯手术的经验。

方法

在324例接受罗斯手术的成人中,204例平均年龄41.3岁(范围16 - 62岁)的患者在1992年10月至2012年2月期间因单纯AS或AS合并反流(AS/AR)接受了该手术,采用IC法植入肺动脉。该组的临床随访和系列超声心动图数据完整性为97%,晚期死亡率随访完整性为99%。

结果

早期死亡率为零(0%),15年的晚期生存率为98%(96%,100%)。仅1例因进行性主动脉反流(AR)而对主动脉瓣进行再次手术,15年主动脉瓣无需再次手术的概率为99%(96%,100%)。15年主动脉瓣和肺动脉瓣均无需再次手术的概率为97%(94%,100%)。最近一次研究的超声心动图分析显示,98%的患者无、微量或轻度AR。长期(15年)超声心动图随访显示主动脉根部大小保持稳定。

结论

在长达19年的经验中,采用所述IC法对以AS为主的患者进行罗斯手术,15年主动脉瓣无需再次手术的概率为99%,优于任何其他组织瓣膜或机械瓣膜。对于65岁以下无明显合并症且以AS为主的成人患者,采用该技术植入的自体肺动脉瓣效果极佳。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2fe/3991211/4f9598c7a8b8/gcsp-2013-383-g001.jpg

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