Gupta Tripti, Giangrande Angela
Institut de Génétique et de Biologie Moléculaire et Cellulaire, IGBMC/CNRS/INSERM/UDS , Illkirch-Graffenstaden , France.
J Neurogenet. 2014 Sep-Dec;28(3-4):190-8. doi: 10.3109/01677063.2014.896911. Epub 2014 May 7.
Cell migration is a key mechanism during neural development, as it allows cells to reach their final destination from their birthplace. In some cases, cells migrate in isolation, whereas in others they migrate in collectives, as chains, streams, clusters, or sheets. The coordinated and timely process of collective migration eventually ensures the proper organization of the nervous system and its misregulation leads to severe diseases, including neurological disorders. This review impinges upon the cellular and molecular interactions underlying collective cell migration in animal models, and highlights the recent advances made through in vivo analyses of the Drosophila wing glia.
细胞迁移是神经发育过程中的关键机制,因为它使细胞能够从其诞生地到达最终目的地。在某些情况下,细胞单独迁移,而在其他情况下,它们以集体形式迁移,如链状、溪流状、簇状或片状。集体迁移的协调且及时的过程最终确保了神经系统的正常组织,其失调会导致包括神经疾病在内的严重疾病。本综述探讨了动物模型中集体细胞迁移背后的细胞和分子相互作用,并强调了通过对果蝇翅神经胶质细胞的体内分析所取得的最新进展。