Ilhan Nevin, Celik Ebru, Kumbak Banu
Department of Biochemistry, School of Medicine, Fırat University , Elazig , Turkey .
J Matern Fetal Neonatal Med. 2015 Feb;28(3):316-9. doi: 10.3109/14767058.2014.916674. Epub 2014 May 22.
Preterm premature rupture of membranes (PPROM) is associated with significant maternal and perinatal morbidity. This study examined maternal oxidative stress in PPROM.
This was a prospective cross-sectional study conducted in a university hospital. A total of 72 pregnant women were recruited into two groups, those with PPROM (38 cases) and those without PPROM (34 controls) matched for gestational age. Plasma interleukin-6, C-reactive protein, vitamins C, E and A, 8-isoprostane, total oxidant status (TOS) and antioxidant status (TAS) were determined for all study participants and the data were compared between the PPROM and control groups.
Both case and control groups were comparably matched in age, parity, gestational age and smoking status. There was a significant association between low 8-isoprostane, low vitamin C and high total oxidant status and the occurrence of PPROM (p < 0.001).
Plasma vitamin C and 8-isoprostane levels were lower and TOS higher in women with PPROM. Further research is needed to identify robust biological markers for the prevention and also prognosis of PPROM.
胎膜早破（PPROM）与孕产妇和围产儿的显著发病相关。本研究检测了PPROM患者的母体氧化应激情况。
这是一项在大学医院进行的前瞻性横断面研究。共招募了72名孕妇，分为两组，即胎膜早破组（38例）和无胎膜早破组（34例对照），两组孕周匹配。测定了所有研究参与者的血浆白细胞介素-6、C反应蛋白、维生素C、E和A、8-异前列腺素、总氧化剂状态（TOS）和抗氧化剂状态（TAS），并对胎膜早破组和对照组的数据进行了比较。
病例组和对照组在年龄、产次、孕周和吸烟状况方面具有可比性。低8-异前列腺素、低维生素C和高总氧化剂状态与PPROM的发生之间存在显著关联（p < 0.001）。
PPROM患者的血浆维生素C和8-异前列腺素水平较低，而TOS较高。需要进一步研究以确定用于PPROM预防和预后的可靠生物学标志物。
