Öztürk Erman, Oral Alihan, Özdemir Melek, Bambul Nail
Department of Hematology, Istanbul Medeniyet University, Göztepe Training and Research Hospital , Istanbul , Turkey , and.
Platelets. 2015;26(3):258-9. doi: 10.3109/09537104.2014.898263. Epub 2014 Apr 21.
Immune thrombocytopenia (ITP) is a heterogeneous disease which can be primary or secondary due to other conditions such as drugs. CB2 receptors (CB2R) also have a role in the ITP pathogenesis as CB2 receptor gene (CNR2) polymorphisms are associated with chronic immune thrombocytopenia and autoimmune diseases. K2 is synthetic marijuana which acts on cannabinoid receptors that are found on immune cells and thrombocytes. Here, we present a case who presented with ITP secondary to K2 usage and was successfully treated with 1 mg/kg prednisolone. This is the first ITP case in the literature due to K2. It is important in the era of the new drugs development of the CB2R mimetics.
免疫性血小板减少症（ITP）是一种异质性疾病，可分为原发性或继发性，后者是由其他因素如药物引起的。CB2受体（CB2R）在ITP发病机制中也起作用，因为CB2受体基因（CNR2）多态性与慢性免疫性血小板减少症和自身免疫性疾病有关。K2是一种合成大麻素，作用于免疫细胞和血小板上发现的大麻素受体。在此，我们报告一例因使用K2继发ITP的病例，该病例成功接受了1mg/kg泼尼松龙治疗。这是文献中首例因K2导致的ITP病例。这在CB2R模拟物新药研发时代具有重要意义。
