慢性肾脏病中的心血管病理生理学：从疾病到健康的转变机会。
Cardiovascular pathophysiology in chronic kidney disease: opportunities to transition from disease to health.
机构信息
Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
出版信息
Ann Glob Health. 2014 Jan-Feb;80(1):69-76. doi: 10.1016/j.aogh.2013.12.007. Epub 2013 Dec 25.
BACKGROUND
Chronic kidney disease (CKD) is common, and is associated with a high burden of cardiovascular disease. This cardiovascular risk is incompletely explained by traditional risk factors, calling attention to a need to better understand the pathways in CKD contributing to adverse cardiovascular outcomes.
FINDINGS
Pathophysiological derangements associated with CKD, including disordered sodium, potassium, and water homeostasis, renin-angiotensin-aldosterone and sympathetic activity, anemia, bone and mineral metabolism, uremia, and toxin accumulation may contribute directly to progression of cardiovascular disease and adverse outcomes.
CONCLUSION
Improving cardiovascular health in patients with CKD requires improved understanding of renocardiac pathophysiology. Ultimately, the most successful strategy may be prevention of incident CKD itself.
背景
慢性肾脏病（CKD）很常见，并且与心血管疾病的负担很高有关。这种心血管风险不能用传统的危险因素完全解释，这就需要更好地了解 CKD 中导致不良心血管结局的途径。
发现
与 CKD 相关的病理生理紊乱，包括钠、钾和水稳态紊乱、肾素-血管紧张素-醛固酮和交感神经活动、贫血、骨骼和矿物质代谢、尿毒症和毒素积累，可能直接导致心血管疾病的进展和不良结局。
结论
改善 CKD 患者的心血管健康需要更好地了解肾心病理生理学。最终，最成功的策略可能是预防 CKD 的发生本身。
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