Utilization of magnetic-activated cell sorting and high-density single nucleotide polymorphism microarrays improves diagnostic yield and prognostic value in clinical testing for patients with multiple myeloma and normal routine chromosome study.
作者信息
Christensen Todd, Deng Weiwen, McMahill Bonnie, Schappert Joseph, Liu Weihua, Saleki Reza, Zou Ying S
出版信息
Acta Haematol. 2014;132(2):233-6. doi: 10.1159/000361074.
Abstract
摘要
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Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma.16号染色体杂合性缺失的基因定位与表达分析确定WWOX和CYLD在决定多发性骨髓瘤的临床结局中起重要作用。
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Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantation.通过荧光原位杂交检测发现浆细胞发育异常中常见1q21染色体带的增加：发生率从意义未明的单克隆丙种球蛋白病（MGUS）到复发骨髓瘤逐渐升高，且与串联干细胞移植后的预后和疾病进展相关。
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