Child Study Center, Yale University, New Haven, CT, USA.
Mental Health Center, Shantou University, Shantou, Guangdong, People's Republic of China.
Mol Psychiatry. 2014 Jun;19(6):641-51. doi: 10.1038/mp.2014.35. Epub 2014 Apr 22.
Prenatal stress is a risk factor for several psychiatric disorders in which inhibitory neuron pathology is implicated. A growing body of research demonstrates that inhibitory circuitry in the brain is directly and persistently affected by prenatal stress. This review synthesizes research that explores how this early developmental risk factor impacts inhibitory neurons and how these findings intersect with research on risk factors and inhibitory neuron pathophysiology in schizophrenia, anxiety, autism and Tourette syndrome. The specific impact of prenatal stress on inhibitory neurons, particularly developmental mechanisms, may elucidate further the pathophysiology of these disorders.
产前应激是几种精神疾病的风险因素，其中涉及抑制性神经元病理学。越来越多的研究表明，大脑中的抑制性电路直接且持续受到产前应激的影响。这篇综述综合了研究成果，探讨了这种早期发育风险因素如何影响抑制性神经元，以及这些发现如何与精神分裂症、焦虑症、自闭症和妥瑞氏综合征的风险因素和抑制性神经元病理生理学研究相交叉。产前应激对抑制性神经元的具体影响，特别是发育机制，可能进一步阐明这些疾病的病理生理学。
