Clyne L P, Farber L R, Chopyk R L
Department of Clinical Laboratories, Yale New Haven Hospital, Connecticut.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1989;116(2):239-44.
A 70 year old male patient admitted for coronary bypass surgery presented with a procainamide-induced lupus syndrome. This syndrome included a LLAC with a positive IgM ACA titer as well as a factor XII inhibitor. These drug-induced inhibitors were superimposed upon the patient's congenital deficiency of factor XI. The methods used to identify these abnormalities are described together with the replacement therapy employed to cover the surgical procedure. The long-term withdrawal of procainamide was associated with correction of all coagulation abnormalities except the factor XI deficiency.
一名因冠状动脉搭桥手术入院的70岁男性患者出现了普鲁卡因胺诱发的狼疮综合征。该综合征包括抗心磷脂抗体（IgM ACA）滴度阳性的狼疮抗凝物（LLAC）以及因子Ⅻ抑制剂。这些药物诱发的抑制剂叠加在患者先天性因子Ⅺ缺乏的基础上。文中描述了用于识别这些异常的方法以及为覆盖手术过程所采用的替代疗法。长期停用普鲁卡因胺后，除因子Ⅺ缺乏外，所有凝血异常均得到纠正。
