Liu Wei, Xiong Xing-Jiang, Wang Jie
Zhongguo Zhong Yao Za Zhi. 2014 Jan;39(1):14-9.
Hypertensive renal damage is based on the extent and duration of hypertension, renal damage caused by varying severity. Hypertensive renal damage due to various causes imbalance of vascular active substances, renal arteriosclerosis, so that the abnormal renal hemodynamic, renal ischemia, low specific gravity of urine, low osmotic pressure and urine. The rapidly increasing incidence of hypertensive renal damage has become one of the most important reasons of end stage renal disease (ESRD). Effective treatment of hypertension is limited by poor compliance and significant adverse reaction of antihypertensive drugs. Therefore, some patients have turned to Chinese medicine (CM), hoping that such treatments might improve the efficiency. The author reviews relevant theory and the latest researches, on the basis of combining diseases and syndrome, discusses state and achievement of hypertensive renal damage with Chinese herbal medicines from fundamental and clinical research and action mechanism from standpoints of Chinese herbal compound and herbal effective chemical composition to take future research for important reference.
高血压肾损害取决于高血压的程度和持续时间,会导致不同严重程度的肾损害。各种原因引起的高血压肾损害是由于血管活性物质失衡、肾动脉硬化,从而使肾脏血流动力学异常、肾缺血、尿比重低、尿渗透压降低。高血压肾损害的发病率迅速上升,已成为终末期肾病(ESRD)的最重要原因之一。高血压的有效治疗受到患者依从性差和抗高血压药物显著不良反应的限制。因此,一些患者转向中医,希望此类治疗可能提高疗效。作者回顾相关理论和最新研究,在病证结合的基础上,从基础研究和临床研究方面探讨高血压肾损害的中医治疗现状与成果,并从中药复方和中药有效化学成分角度探讨其作用机制,以供未来研究参考。