Yang Xin-Bao, Yang Xiu-Wei, Liu Jian-Xun
Zhongguo Zhong Yao Za Zhi. 2014 Jan;39(1):20-7.
Corydalis Rhizoma, the dried tuber of Corydalis yanhusuo (Papaveraceae) distributed traditionally mainly in south-eastern and now cultivated in northwestern and other district in China, is one of the commonly used and well-known traditional Chinese medicine. It has been widely used to treat spastic pain, abdominal pain, pain due to injury, and promote blood circulation. Its main chemical constituents were alkaloids, which were divided into the two types of protoberberines and aporphines. Among them, some alkaloids were found to elicit profound effects on the dopaminergic system in the central nervous system, which plays an important role in regulating nociception. In this article, the chemical composition and structure-types, new methods of qualitative and quantitative analysis as well as characteristics of biotransformation, absorption, distribution, metabolism, excretion, pharmacokinetic, and drug-drug interaction for the alkaloids were revealed. These results would greatly contribute to the establishment of bioactive material base of Corydalis Rhizoma.
延胡索，为罂粟科植物延胡索干燥块茎，传统上主要分布于中国东南部，现中国西北及其他地区也有栽培，是常用且著名的一味中药。它被广泛用于治疗痉挛性疼痛、腹痛、伤痛，并促进血液循环。其主要化学成分是生物碱，分为原小檗碱型和阿朴啡型两类。其中，一些生物碱被发现对中枢神经系统的多巴胺能系统有显著影响，该系统在调节伤害感受中起重要作用。本文揭示了延胡索生物碱的化学成分、结构类型、定性定量分析新方法以及生物转化、吸收、分布、代谢、排泄、药代动力学和药物相互作用的特点。这些结果将极大地有助于建立延胡索的生物活性物质基础。
