Cardiology Department, Soroka Medical Center and Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Cardiology Department, Soroka Medical Center and Ben-Gurion University of the Negev, Beer-Sheva, Israel
Angiology. 2015 Mar;66(3):262-4. doi: 10.1177/0003319714531646. Epub 2014 Apr 21.
Coronary atherosclerosis is a progressive disease. We sought to determine whether this fact also applies to patients at an advanced age with normal coronary arteries (NCAs) undergoing repeat catheterization at least 5 years later. Of the 189 patients who were found to have NCAs, 154 (81%) remained with NCAs and 35 (19%) developed obstructive coronary artery disease (OCAD). Development of OCAD was observed at all ages. Isolated risk factors were not associated with the appearance of OCAD, but the combination of diabetes mellitus with age >65 years or with smoking was associated with the appearance of OCAD (P = .04 for both). In conclusion, the finding of angiographically NCAs in elderly individuals does not prevent the later development of OCAD.
冠状动脉粥样硬化是一种进行性疾病。我们试图确定这一事实是否也适用于至少 5 年后再次接受导管检查的年龄较大且冠状动脉正常 (NCA) 的患者。在 189 名被发现存在 NCA 的患者中，154 名 (81%) 仍存在 NCA，35 名 (19%) 发展为阻塞性冠状动脉疾病 (OCAD)。在所有年龄段都观察到了 OCAD 的发展。孤立的危险因素与 OCAD 的出现无关，但糖尿病与年龄 >65 岁或与吸烟相结合与 OCAD 的出现有关 (两者均为 P =.04)。总之，在老年人中发现血管造影 NCA 并不能预防后期 OCAD 的发生。
