瞬时受体电位香草酸亚型2

TRPV2.

作者信息

Kojima Itaru, Nagasawa Masahiro

机构信息

Department of Cell Biology, Institute for Molecular & Cellular Regulation, Gunma University, Maebashi, Gunma Prefecture, 371-8511, Japan,

出版信息

Handb Exp Pharmacol. 2014;222:247-72. doi: 10.1007/978-3-642-54215-2_10.

DOI:10.1007/978-3-642-54215-2_10

PMID:24756709

Abstract

Transient receptor potential vanilloid type 2, TRPV2, is a calcium-permeable cation channel belonging to the TRPV channel family. This channel is activated by heat (>52 °C), various ligands, and mechanical stresses. In most of the cells, a large portion of TRPV2 is located in the endoplasmic reticulum under unstimulated conditions. Upon stimulation of the cells with phosphatidylinositol 3-kinase-activating ligands, TRPV2 is translocated to the plasma membrane and functions as a cation channel. Mechanical stress may also induce translocation of TRPV2 to the plasma membrane. The expression of TRPV2 is high in some types of cells including neurons, neuroendocrine cells, immune cells involved in innate immunity, and certain types of cancer cells. TRPV2 may modulate various cellular functions in these cells.

摘要

瞬时受体电位香草酸亚型2（TRPV2）是一种属于TRPV通道家族的钙通透性阳离子通道。该通道可被热（>52°C）、各种配体和机械应力激活。在大多数细胞中，在未受刺激的条件下，大部分TRPV2位于内质网中。在用磷脂酰肌醇3激酶激活配体刺激细胞后，TRPV2转位至质膜并作为阳离子通道发挥作用。机械应力也可能诱导TRPV2转位至质膜。TRPV2在某些类型的细胞中高表达，包括神经元、神经内分泌细胞、参与固有免疫的免疫细胞以及某些类型的癌细胞。TRPV2可能调节这些细胞中的各种细胞功能。