Gries J, Kretzschmar R, Neumann B W
Department of Pharmacology, Knoll AG, Ludwigshafen, F.R.G.
J Cardiovasc Pharmacol. 1989;13 Suppl 4:S79-82. doi: 10.1097/00005344-198900134-00024.
In stroke-prone spontaneously hypertensive rats, oral long-term treatment with verapamil, propranolol, hydrochlorothiazide, and dihydralazine attenuated the development of hypertension. The various antihypertensive drugs caused comparable reductions in blood pressure but the calcium antagonist and the beta-receptor blocker prolonged the life span more than the diuretic and vasodilator. The relative heart and lung weights at the time of death were slightly diminished in the verapamil and the high-dose propranolol group. It is assumed that calcium antagonism and beta-receptor blockade prolong the life span, not only due to their blood-pressure-lowering mechanism, but also to the additional protective effects.
在易患中风的自发性高血压大鼠中，长期口服维拉帕米、普萘洛尔、氢氯噻嗪和肼屈嗪可减缓高血压的发展。各种抗高血压药物导致的血压降低程度相当，但钙拮抗剂和β受体阻滞剂比利尿剂和血管扩张剂更能延长寿命。维拉帕米组和高剂量普萘洛尔组死亡时的相对心脏和肺重量略有减轻。据推测，钙拮抗作用和β受体阻滞不仅因其降压机制，还因其额外的保护作用而延长寿命。
