Ikeda M, Ishikura A, Kogure Y
Neurol Med Chir (Tokyo). 1989 Feb;29(2):128-31. doi: 10.2176/nmc.29.128.
A 76-year-old female developed depression and loss of appetite. On admission, in June of 1987, she was disoriented. Computed tomography (CT) revealed enhanced masses without perifocal edema in the cerebellar vermis and left occipital lobe. The cerebellar tumor was subtotally removed through a suboccipital craniectomy. Histological examination disclosed malignant lymphoma of the diffuse, large cell type. The patient underwent postoperative irradiation, and no other tumors were detected by whole-body CT or gallium scans. Her 51-year-old son had been admitted to another hospital in April of 1987, with complaints of depression and change in mental status. Neurological examination revealed right hemiparesis, and CT demonstrated an enhanced left frontal paraventricular mass and severe perifocal edema. The histological diagnosis was malignant lymphoma, and the patient received postoperative irradiation and chemotherapy. A few cases of familial extracranial malignant lymphoma have been described. However, to the authors' knowledge, this is the first reported occurrence of familial primary intracranial malignant lymphoma.
一名76岁女性出现抑郁和食欲不振症状。1987年6月入院时，她意识模糊。计算机断层扫描（CT）显示小脑蚓部和左枕叶有强化肿块，周围无水肿。通过枕下颅骨切除术对小脑肿瘤进行了次全切除。组织学检查显示为弥漫性大细胞型恶性淋巴瘤。患者接受了术后放疗，全身CT或镓扫描未发现其他肿瘤。她51岁的儿子于1987年4月因抑郁和精神状态改变入住另一家医院。神经学检查发现右半身轻瘫，CT显示左额叶脑室旁有强化肿块及严重的周围水肿。组织学诊断为恶性淋巴瘤，该患者接受了术后放疗和化疗。已有少数家族性颅外恶性淋巴瘤病例的报道。然而，据作者所知，这是首次报道的家族性原发性颅内恶性淋巴瘤病例。
