新合成的芳香族C-核苷衍生物的抗氧化和抗肿瘤活性
Antioxidant and antitumor activities of new synthesized aromatic C-nucleoside derivatives.
作者信息
El Sadek Mohamed M, Abd El-Dayem Nagwa S, Hassan Seham Y, Mostafa Mohamed A, Yacout Galila A
机构信息
Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt.
Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt.
出版信息
Molecules. 2014 Apr 22;19(4):5163-90. doi: 10.3390/molecules19045163.
The carbohydrazide 1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole 7, [1,3,4]oxadiazolo[2,3-a]isoindole 10b and pyrazole units 18. On the other hand, the thiosemicarbazone 20 was used as the key intermediate for synthesis of 1,3,4-oxadiazole and 1,2,4-triazole-3-thione derivatives 21 and 23. The antioxidant activities of the prepared compounds were evaluated. The carbohydrazide 1 in particular was found to have potent antioxidant and antitumor activity.
酰肼1被用作合成多种含有1,3,4-恶二唑7、[1,3,4]恶二唑并[2,3-a]异吲哚10b和吡唑单元18的新型芳香族C-核苷的前体。另一方面，硫代半卡巴腙20被用作合成1,3,4-恶二唑和1,2,4-三唑-3-硫酮衍生物21和23的关键中间体。对所制备化合物的抗氧化活性进行了评估。尤其发现酰肼1具有有效的抗氧化和抗肿瘤活性。
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