新型 2'-脱氧-2'-氟-2'-C-甲基核苷类似物的合成及抗 HCV 活性。
Synthesis and anti-HCV activity of a new 2'-deoxy-2'-fluoro-2'-C-methyl nucleoside analogue.
机构信息
Department of Chemistry, Zhengzhou University, Zhengzhou, Henan Province, PR China.
出版信息
Bioorg Med Chem Lett. 2010 Dec 15;20(24):7297-8. doi: 10.1016/j.bmcl.2010.10.076. Epub 2010 Nov 4.
PMID:21106452
Abstract
2'-Deoxy-2'-fluoro-2'-C-methyl nucleoside analogue 4 was designed and synthesized. Initial biological studies indicated that this compound showed promising activity against HCV replication.
摘要
2'-脱氧-2'-氟-2'-C-甲基核苷类似物 4 被设计和合成。初步的生物学研究表明，该化合物对 HCV 复制显示出有希望的活性。
Zotero 插件