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出生体重与口吃:来自三个出生队列的证据。

Birth weight and stuttering: Evidence from three birth cohorts.

机构信息

School of Rehabilitation Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom.

Faculty of Social Sciences, University of East Anglia, Norwich, United Kingdom.

出版信息

J Fluency Disord. 2014 Mar;39:25-33. doi: 10.1016/j.jfludis.2013.10.002. Epub 2013 Nov 2.

Abstract

PURPOSE

Previous studies have produced conflicting results with regard to the association between birth weight and developmental stuttering. This study sought to determine whether birth weight was associated with childhood and/or adolescent stuttering in three British birth cohort samples.

METHODS

Logistic regression analyses were carried out on data from the Millenium Cohort Study (MCS), British Cohort Study (BCS70) and National Child Development Study (NCDS), whose initial cohorts comprised over 56,000 individuals. The outcome variables were parent-reported stuttering in childhood or in adolescence; the predictors, based on prior research, were birth weight, sex, multiple birth status, vocabulary score and mother's level of education. Birth weight was analysed both as a categorical variable (low birth weight, <2500g; normal range; high birth weight, ≥4000g) and as a continuous variable. Separate analyses were carried out to determine the impact of birth weight and the other predictors on stuttering during childhood (age 3, 5 and 7 and MCS, BCS70 and NCDS, respectively) or at age 16, when developmental stuttering is likely to be persistent.

RESULTS

None of the multivariate analyses revealed an association between birth weight and parent-reported stuttering. Sex was a significant predictor of stuttering in all the analyses, with males 1.6-3.6 times more likely than females to stutter.

CONCLUSION

Our results suggest that birth weight is not a clinically useful predictor of childhood or persistent stuttering.

摘要

目的

先前的研究对于出生体重与发展性口吃之间的关联得出了相互矛盾的结果。本研究旨在确定在三个英国出生队列样本中,出生体重是否与儿童期和/或青少年口吃有关。

方法

对千禧年队列研究(MCS)、英国队列研究(BCS70)和全国儿童发展研究(NCDS)的数据进行逻辑回归分析,这些研究的初始队列包含超过 56000 人。因变量是父母报告的儿童期或青少年期口吃;基于先前的研究,预测因子是出生体重、性别、多胎出生情况、词汇得分和母亲的教育水平。出生体重既作为分类变量(低出生体重,<2500g;正常范围;高出生体重,≥4000g)进行分析,也作为连续变量进行分析。分别进行分析,以确定出生体重和其他预测因子对儿童期(3、5 和 7 岁,分别对应 MCS、BCS70 和 NCDS)或 16 岁时口吃的影响,此时发展性口吃可能持续存在。

结果

多元分析均未显示出生体重与父母报告的口吃之间存在关联。性别是所有分析中口吃的一个重要预测因子,男性口吃的可能性是女性的 1.6-3.6 倍。

结论

我们的结果表明,出生体重不是儿童期或持续性口吃的临床有用预测因子。

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