Ramqvist T, Reinholdsson G, Carlquist M, Bergman T, Dalianis T
Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
Virology. 1989 Sep;172(1):359-62. doi: 10.1016/0042-6822(89)90140-2.
Polyoma virus, an oncogenic virus, fails to induce tumors in immunocompetent rodents due to T cell-dependent mechanisms. The target recognized by the immune system has been functionally defined as polyoma tumor-specific transplantation antigen (TSTA) and has been postulated to be related to the virus three early proteins small T (ST), middle T (MT), and large T (LT) antigens. We show here that immunization with a synthetic peptide corresponding to amino acids 162-176 of polyoma MT and ST was able to decrease tumor progression of polyoma tumors, but not of nonpolyoma tumors. This indicated that these amino acids constitute an epitope of the polyoma tumor-specific transplantation antigen.
多瘤病毒是一种致癌病毒，由于T细胞依赖性机制，它无法在免疫功能正常的啮齿动物中诱发肿瘤。免疫系统识别的靶标在功能上被定义为多瘤肿瘤特异性移植抗原（TSTA），并且据推测与病毒的三种早期蛋白小T（ST）、中T（MT）和大T（LT）抗原有关。我们在此表明，用对应于多瘤病毒MT和ST氨基酸162 - 176的合成肽进行免疫能够减少多瘤肿瘤的进展，但不能减少非多瘤肿瘤的进展。这表明这些氨基酸构成了多瘤肿瘤特异性移植抗原的一个表位。
