四氧嘧啶诱导的糖尿病所致尿道功能障碍。枸橼酸西地那非的尿动力学评估及作用
Urethral dysfunction due to alloxan-induced diabetes. Urodynamic evaluation and action of sildenafil citrate.
作者信息
Gomes de Souza Pegorare Ana Beatriz, Gonçalves Marco Antonio, Martiniano de Oliveira Alessandra, Rodrigues Junior Antonio Antunes, Tucci Silvio, Suaid Haylton Jorge
机构信息
Department of Surgery and Anatomy, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Department of Surgery and Anatomy, FMRP, USP, Ribeirao Preto, SP, Brazil.
出版信息
Acta Cir Bras. 2014 Apr;29(4):274-9. doi: 10.1590/s0102-86502014000400009.
PURPOSE
To evaluate the effect of diabetes mellitus and of sildenafil citrate on female urethral function.
METHODS
Twenty nine female rats were divided into four groups: G1 - (n=9), normal rats; G2 - (n=6), normal rats treated with sildenafil citrate; G3 - (n=9) rats with alloxan-induced diabetes; G4 - (n=5) rats with alloxan-induced diabetes treated with sildenafil citrate. Under anesthesia, urodynamic evaluation was performed by cystometry and urethral pressure simultaneously.
RESULTS
A significant increase in urethral pressure was observed during micturition.
CONCLUSION
Sildenafil citrate can partially reduced urethral pressure in diabetic female rats.
目的
评估糖尿病及枸橼酸西地那非对雌性尿道功能的影响。
方法
29只雌性大鼠分为四组：G1组（n = 9），正常大鼠；G2组（n = 6），用枸橼酸西地那非治疗的正常大鼠；G3组（n = 9），用四氧嘧啶诱导糖尿病的大鼠；G4组（n = 5），用枸橼酸西地那非治疗的四氧嘧啶诱导糖尿病的大鼠。在麻醉状态下，通过膀胱测压和尿道压力同步进行尿动力学评估。
结果
排尿期间观察到尿道压力显著升高。
结论
枸橼酸西地那非可部分降低糖尿病雌性大鼠的尿道压力。
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