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肥胖糖尿病患者行Roux-en-Y胃旁路术后高血压的控制

Control of hypertension after roux-en-y gastric bypass among obese diabetic patients.

作者信息

Cazzo Everton, Gestic Martinho Antonio, Utrini Murillo Pimentel, Machado Ricardo Rossetto, Pareja José Carlos, Chaim Elinton Adami

机构信息

Departamento de Cirurgia, Grupo de Cirurgia de Obesidade, Universidade de Campinas ? UNICAMP, Campinas, São Paulo, Brasil.

出版信息

Arq Gastroenterol. 2014 Jan-Mar;51(1):21-4. doi: 10.1590/s0004-28032014000100005.

Abstract

CONTEXT

Hypertension is a common disorder in general practice and has a widely known association with type 2 diabetes mellitus. Low adhesion to clinical treatment may lead to poor results. Obesity surgery can bring early and relevant resolution rates of both morbidities.

OBJECTIVE

To describe hypertension evolution after Roux-en-Y gastric bypass in patients with type 2 diabetes mellitus.

METHOD

Descriptive observational study designed as a historical cohort of 90 subjects with hypertension and diabetes who underwent Roux-en-Y gastric bypass and were evaluated before and after surgery.

RESULTS

It was observed a hypertension resolution rate of 85.6% along with markedly decrease in anti-hypertensive usage. Mean resolution time was 3.2 months. Resolution was associated with homeostasis model assessment - insulin resistance, preoperative fasting insulin, anti-hypertensive usage, hypertension time, body mass index and percentage of weight loss. Resolution of hypertension was not statistically associated with diabetes remission within this sample.

CONCLUSION

Roux-en-Y gastric bypass was a safe and effective therapeutic tool to achieve hypertension resolution in patients who also had diabetes mellitus.

摘要

背景

高血压是全科医疗中的常见病症,且与2型糖尿病的关联广为人知。临床治疗依从性低可能导致疗效不佳。肥胖症手术可使这两种病症早期获得显著缓解率。

目的

描述2型糖尿病患者接受Roux-en-Y胃旁路术后高血压的演变情况。

方法

描述性观察性研究,设计为对90例患有高血压和糖尿病且接受了Roux-en-Y胃旁路术的患者进行历史队列研究,并在手术前后进行评估。

结果

观察到高血压缓解率为85.6%,同时抗高血压药物的使用显著减少。平均缓解时间为3.2个月。缓解与稳态模型评估-胰岛素抵抗、术前空腹胰岛素、抗高血压药物使用、高血压病程、体重指数和体重减轻百分比有关。在该样本中,高血压的缓解与糖尿病缓解无统计学关联。

结论

对于同时患有糖尿病的患者,Roux-en-Y胃旁路术是实现高血压缓解的一种安全有效的治疗手段。

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