Rieger Robert, Schuettler Martin, Chuang Sheng-Chih
IEEE Trans Neural Syst Rehabil Eng. 2014 Sep;22(5):937-45. doi: 10.1109/TNSRE.2014.2300933. Epub 2014 Jan 16.
This paper describes a device that emulates propagation of action potentials along a peripheral nerve, suitable for reproducible testing of bio-potential recording systems using nerve cuff electrodes. The system is a microcontroller-based stand-alone instrument which uses established nerve and electrode models to represent neural activity of real nerves recorded with a nerve cuff interface, taking into consideration electrode impedance, voltages picked up by the electrodes, and action potential propagation characteristics. The system emulates different scenarios including compound action potentials with selectable propagation velocities and naturally occurring nerve traffic from different velocity fiber populations. Measured results from a prototype implementation are reported and compared with in vitro recordings from Xenopus Laevis frog sciatic nerve, demonstrating that the electrophysiological setting is represented to a satisfactory degree, useful for the development, optimization and characterization of future recording systems.
本文描述了一种模拟动作电位沿外周神经传播的装置，适用于使用神经袖套电极对生物电位记录系统进行可重复测试。该系统是基于微控制器的独立仪器，它使用已建立的神经和电极模型来表示通过神经袖套接口记录的真实神经的神经活动，同时考虑电极阻抗、电极采集的电压以及动作电位传播特性。该系统模拟不同场景，包括具有可选传播速度的复合动作电位以及来自不同速度纤维群体的自然神经活动。报告了原型实现的测量结果，并与非洲爪蟾坐骨神经的体外记录进行了比较，表明电生理设置得到了令人满意的呈现，对未来记录系统的开发、优化和特性表征很有用。
