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杀草丹对白化大鼠（Wistar品系）脑内Mg2 + -ATP酶的抑制动力学及其肟类化合物和L-半胱氨酸的恢复作用

Kinetics of Mg2+-ATPase inhibition by benthiocarb and its recovery by oximes and L-cysteine in brain of albino rat (Wistar strain).

作者信息

Veera Babu G R, Ramesh Reddy G, Chetty C S

机构信息

Department of Zoology, S. V. University, Tirupati, India.

出版信息

Arch Int Physiol Biochim. 1989 Apr;97(2):205-9. doi: 10.3109/13813458909104540.

DOI:10.3109/13813458909104540
PMID:2476098
Abstract

Effects in vitro of benthiocarb on rat brain Mg2+-ATPase were studied to elucidate the interaction of benthiocarb with Mg2+-ATPase. Based on IC50 values, it was evident that Mg2+-ATPase was sensitive to benthiocarb. Non-competitive inhibition with respect to activation by ATP was indicated by decreased maximal velocity (V) without change in Michaelis Menten constant (Km). It was also noted that pyridine-2-aldoxime (30 microM), pyridine-4-aldoxime (35 microM) and L-cysteine (90 microM) neutralized the inhibition of benthiocarb (8 microM).

摘要

为阐明杀草丹与Mg2+-ATP酶的相互作用，研究了杀草丹对大鼠脑Mg2+-ATP酶的体外效应。根据半数抑制浓度（IC50）值，很明显Mg2+-ATP酶对杀草丹敏感。ATP激活作用的非竞争性抑制表现为最大速度（V）降低，而米氏常数（Km）不变。还注意到，吡啶-2-醛肟（30微摩尔）、吡啶-4-醛肟（35微摩尔）和L-半胱氨酸（90微摩尔）可中和杀草丹（8微摩尔）的抑制作用。

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