Alrazzak Muaz A, Zablahalabi Jenny, Alrazzak Baraa, De Angulo Guillermo
Department of Pediatrics, Roswell Park Cancer Institute, Buffalo, New York, United States.
Department of Pediatrics, Miami Children's Hospital, Miami, Florida, United States.
Avicenna J Med. 2014 Apr;4(2):48-50. doi: 10.4103/2231-0770.130347.
Childhood neoplasms are relatively rare and represent only about 1- 2% of the total incidence of neoplasms in United States. Concurrent episode of childhood cancer is uncommon and usually related to a cancer genetic syndrome. Li Fraumeni Syndrome refers to an autosomal dominant condition that is manifested by the development of certain cancers in early childhood and an increased lifetime risk for developing multiple primary cancers including sarcoma, breast cancer, leukemia, bone cancer, and others. We report a case of a 21-month-old girl who was found to have orbital embryonal rhabdomyosarcoma and adrenocortical tumor concurrently.
儿童肿瘤相对罕见，仅占美国肿瘤总发病率的约1%-2%。儿童癌症并发情况并不常见，通常与癌症遗传综合征有关。李-弗劳梅尼综合征是一种常染色体显性疾病，表现为儿童早期发生某些癌症，以及患多种原发性癌症（包括肉瘤、乳腺癌、白血病、骨癌等）的终生风险增加。我们报告一例21个月大女童，其同时被发现患有眼眶胚胎性横纹肌肉瘤和肾上腺皮质肿瘤。
