Iles R K, Czepulkowski B H, Young B D, Chard T
Department of Reproductive Physiology, St Bartholomew's Hospital Medical College, London.
J Mol Endocrinol. 1989 Mar;2(2):113-7. doi: 10.1677/jme.0.0020113.
The beta-subunit of human chorionic gonadotrophin (hCG) is coded on chromosome 19 by the beta-hCG-hLH gene cluster. Genomic DNA has been isolated from bladder tumour cell lines which ectopically express beta-hCG. The beta-hCG-hLH gene cluster was probed for possible rearrangement or amplification and cells karyotyped for chromosome 19 abnormalities. No rearrangement or amplification of the gene cluster and no consistent abnormalities of chromosome 19 were found. The expression of beta-hCG by bladder tumours is therefore likely to be the result of altered gene regulation and not a rearrangement or amplification of this gene cluster.
人绒毛膜促性腺激素（hCG）的β亚基由β-hCG-hLH基因簇在19号染色体上编码。已从异位表达β-hCG的膀胱肿瘤细胞系中分离出基因组DNA。对β-hCG-hLH基因簇进行检测，以寻找可能的重排或扩增，并对细胞进行染色体核型分析，以检测19号染色体异常。未发现基因簇的重排或扩增，也未发现19号染色体的一致异常。因此，膀胱肿瘤中β-hCG的表达可能是基因调控改变的结果，而非该基因簇的重排或扩增。
