Bhatti Abu Bakar Hafeez, Khan Amina Iqbal, Siddiqui Neelam, Muzaffar Nargis, Syed Aamir Ali, Shah Mazhar Ali, Jamshed Arif
Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan E-mail :
Asian Pac J Cancer Prev. 2014;15(6):2577-81. doi: 10.7314/apjcp.2014.15.6.2577.
Triple negative breast cancer is associated with aggressive behavior and high risk of local and regional failure. Aggressive surgical intervention is considered suitable. This makes role of breast conserving therapy (BCT) debatable in these patients. The objective of this study was to compare outcome of BCT for triple negative versus non-triple negative breast cancer.
Medical records of patients who underwent breast conserving therapy from 1999 to 2009 at Shaukat Khanum Cancer Hospital and had complete receptor status information were extracted. Patients were divided into triple negative breast cancer (TNBC) and non-TNBC. Patient characteristics, medical treatment modalities and adverse events were compared. Expected five year locoregional recurrence free, disease free and overall survival was calculated. The Cox proportional hazard model was used to identify independent predictors of outcome.
A total of 194 patients with TNBC and 443 with non-TNBC were compared. Significant difference was present for age at presentation (p<0.0001), family history (p=0.005), grade (p<0.0001) and use of hormonal therapy (p<0.0001). The number of locoregional failures, distant failures and mortalities were not significantly different. No significant difference was present in 5 year locoregional recurrence free (96% vs 92%, p=0.3), disease free (75% vs 74%, p=0.7) and overall survival (78% vs 83%, p=0.2). On multivariate analysis, tumor size, nodal involvement and hormonal treatment were independent predictors of negative events.
Breast conserving therapy has comparable outcomes for triple negative and non-triple negative breast cancers.
三阴性乳腺癌具有侵袭性，局部和区域复发风险高。积极的手术干预被认为是合适的。这使得保乳治疗（BCT）在这些患者中的作用存在争议。本研究的目的是比较三阴性乳腺癌与非三阴性乳腺癌保乳治疗的结果。
提取1999年至2009年在沙卡特汗姆癌症医院接受保乳治疗且有完整受体状态信息的患者病历。患者分为三阴性乳腺癌（TNBC）组和非TNBC组。比较患者特征、医疗治疗方式和不良事件。计算预期的五年局部区域无复发生存率、无病生存率和总生存率。采用Cox比例风险模型确定结果的独立预测因素。
共比较了194例TNBC患者和443例非TNBC患者。在就诊年龄（p<0.0001）、家族史（p=0.005）、分级（p<0.0001）和激素治疗使用情况（p<0.0001）方面存在显著差异。局部区域复发、远处复发和死亡的数量无显著差异。五年局部区域无复发生存率（96%对92%，p=0.3）、无病生存率（75%对74%，p=0.7）和总生存率（78%对83%，p=0.2）无显著差异。多因素分析显示，肿瘤大小、淋巴结受累情况和激素治疗是不良事件的独立预测因素。
三阴性乳腺癌和非三阴性乳腺癌的保乳治疗结果具有可比性。
