钯催化的使用甲酰胺作为可转化导向基团的 C(sp²)-H 芳基化反应。
Palladium-catalyzed C(sp²)-H arylation using formamide as a transformable directing group.
机构信息
Department of Bioengineering, College of Life Science and Technology, Jinan University , Guangzhou 510632, China.
出版信息
J Org Chem. 2014 May 16;79(10):4751-6. doi: 10.1021/jo5007043. Epub 2014 May 5.
PMID:24762164
Abstract
A new process for the ortho arylation of formanilides through palladium-catalyzed C-H activation is described. Formamide is reported as a transformable directing group in the transition-metal-catalyzed C-H functionalization reaction. The resulting biarylformanilide products can be readily transformed to the corresponding biarylisocyanides or N-heterocycles.
摘要
描述了一种通过钯催化 C-H 活化进行芳基甲酰胺邻位芳基化的新方法。酰胺被报道为过渡金属催化 C-H 官能化反应中的可转化导向基团。所得的联芳基甲酰胺产物可以很容易地转化为相应的联芳基异氰化物或 N-杂环。
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