Srinivasan K, Radhakrishnamurty R
Indian J Biochem Biophys. 1989 Feb;26(1):34-8.
Dietary intake of beta- and gamma-hexachlorocyclohexane (beta- and gamma-HCH) by albino rats for two weeks (at 800 ppm level) resulted in impairment of lipid metabolism, viz. hyperlipemia and fatty metamorphosis of liver. Liver fat content was increased by both beta- and gamma-HCH. Significant increases were observed in triglyceride and phospholipid fractions of blood in these experimental animals. The incorporation of [14C]acetate and palmitate into liver and blood lipids was higher in HCH pretreated animals, suggesting a higher rate of fat synthesis in liver and of secretion as well.
白化大鼠连续两周（浓度为800 ppm）摄入β-六氯环己烷和γ-六氯环己烷（β-HCH和γ-HCH）会导致脂质代谢受损，即出现高脂血症和肝脏脂肪变性。β-HCH和γ-HCH均使肝脏脂肪含量增加。在这些实验动物的血液中，甘油三酯和磷脂组分显著增加。在经六氯环己烷预处理的动物中，[14C]乙酸盐和棕榈酸盐掺入肝脏和血脂中的比例更高，这表明肝脏中脂肪合成及分泌速率也更高。
