Sun X-Z, Tian X-Y, Wang D-W, Li J
Department of Pediatrics, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, P. R. China.
Eur Rev Med Pharmacol Sci. 2014;18(7):959-64.
The aim of this study was to investigate the effects of Rho kinase inhibitor-Fasudil on hypoxic pulmonary hypertension (HPH) and pulmonary vascular remodeling in rats.
A total of 24 Sprague Dawley rats were evenly randomized into control, model and Fasudil intervention groups. Light and transmission electron microscopy were utilized to observe pulmonary vascular remodeling as well as ultrastructural changes in pulmonary arteriole endothelial cells.
The model group showed apparent pulmonary vascular remodeling, pulmonary arteriole endothelial cell injury, the proliferation and swelling of smooth muscle cells around, and the proliferation of collagen fibers. Fasudil intervention improved pulmonary vascular remodeling as well as relieved pulmonary arteriole endothelial cell injury and the proliferation of smooth muscle cells and collagen fibers.
Fasudil has preventive and reverse effects on HPH, pulmonary vascular remodeling, and pulmonary arteriole endothelial cell injury.
本研究旨在探讨Rho激酶抑制剂法舒地尔对大鼠低氧性肺动脉高压（HPH）及肺血管重塑的影响。
将24只Sprague Dawley大鼠平均随机分为对照组、模型组和法舒地尔干预组。采用光镜和透射电镜观察肺血管重塑及肺小动脉内皮细胞超微结构变化。
模型组出现明显的肺血管重塑、肺小动脉内皮细胞损伤、周围平滑肌细胞增殖和肿胀以及胶原纤维增生。法舒地尔干预改善了肺血管重塑，减轻了肺小动脉内皮细胞损伤以及平滑肌细胞和胶原纤维的增生。
法舒地尔对HPH、肺血管重塑及肺小动脉内皮细胞损伤具有预防和逆转作用。
