口腔癌中的淋巴结转移与生存：与分泌性白细胞蛋白酶抑制因子（SLPI）的蛋白表达相关，而非与中性粒细胞明胶酶相关脂质运载蛋白（LCN2）、肿瘤相关钙信号转导蛋白2（TACSTD2）或血小板反应蛋白2（THBS2）相关。
Nodal metastasis and survival in oral cancer: Association with protein expression of SLPI, not with LCN2, TACSTD2, or THBS2.
作者信息
Noorlag Rob, van der Groep Petra, Leusink Frank K J, van Hooff Sander R, Frank Michaël H, Willems Stefan M, van Es Robert J J
机构信息
Department of Oral and Maxillofacial Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Department of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, The Netherlands.
出版信息
Head Neck. 2015 Aug;37(8):1130-6. doi: 10.1002/hed.23716. Epub 2014 Jul 19.
BACKGROUND
Gene expression profiling revealed a strong signature predicting lymph node metastases in oral squamous cell carcinoma (OSCC). Four of the most predictive genes are secretory leukocyte protease inhibitor (SLPI), lipocalin-2 (LCN2), thrombospondin-2 (THBS2), and tumor-associated calcium signal transducer 2 (TACSTD2). This study correlates their protein expression with lymph node metastases, overall survival (OS), and disease-specific survival (DSS).
METHODS
Two hundred twelve patients with OSCC were included for protein expression analysis by immunohistochemistry.
RESULTS
SLPI expression correlates with lymph node metastases in the whole cohort, not in a subgroup of cT1 to 2N0. SLPI expression correlates with OS (hazard ratio [HR] = 0.61) and DSS (HR = 0.47) in multivariate analysis. LCN2, THBS2, and TACSTD2 show no correlation with lymph node metastases, OS, or DSS.
CONCLUSION
Although SLPI expression correlates with lymph node metastases, it has no additional value in determining lymph node metastases in early oral cancer. However, it is an independent predictor for both OS and DSS and therefore a relevant prognostic biomarker in OSCC.
背景
基因表达谱分析显示，在口腔鳞状细胞癌（OSCC）中存在一个强有力的特征可预测淋巴结转移。其中四个最具预测性的基因分别是分泌型白细胞蛋白酶抑制剂（SLPI）、脂质运载蛋白2（LCN2）、血小板反应蛋白2（THBS2）和肿瘤相关钙信号转导蛋白2（TACSTD2）。本研究将它们的蛋白表达与淋巴结转移、总生存期（OS）和疾病特异性生存期（DSS）进行关联分析。
方法
纳入212例OSCC患者，通过免疫组织化学进行蛋白表达分析。
结果
在整个队列中，SLPI表达与淋巴结转移相关，但在cT1至2N0亚组中不相关。在多因素分析中，SLPI表达与总生存期（风险比[HR]=0.61）和疾病特异性生存期（HR=0.47）相关。LCN2、THBS2和TACSTD2与淋巴结转移、总生存期或疾病特异性生存期均无相关性。
结论
尽管SLPI表达与淋巴结转移相关，但在早期口腔癌中其对确定淋巴结转移并无额外价值。然而，它是总生存期和疾病特异性生存期的独立预测因子，因此是口腔鳞状细胞癌中一个相关的预后生物标志物。
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