Lim Yun-Sung, Lee Yoon Se, Lee Jin-Choon, Lee Byung-Joo, Wang Soo-Geun, Park Hee-June, Nam Su-Bong, Bae Yong-Chan
Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Gyeonggi, Korea; Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea.
J Biomed Mater Res B Appl Biomater. 2015 Jan;103(1):47-51. doi: 10.1002/jbm.b.33189. Epub 2014 Apr 25.
We evaluated the efficacy and outcome of intracordal auricular cartilage injection in patients with unilateral vocal fold paralysis. Our interest developed from findings of a canine model study that reported that histologic characteristics of cartilage were preserved 2 and 3 years after intracordal autologous cartilage injection. Between May 2002 and July 2010, 29 patients with breathy dysphonia caused by unilateral vocal fold paralysis underwent intracordal auricular cartilage injection. Each subject underwent preoperative and postoperative perceptual assessments, acoustical voice analysis, and videostroboscopy. Fourteen patients were male, and the mean age was 52-years old. Patients were tracked for a mean duration of 257 days. Injections were performed through a transoral approach under general anesthesia. Perceptual assessments by GRBAS scale, acoustic parameters of jitter, shimmer, noise-to-harmonic ratio, and maximum phonation time significantly improved at 3, 6, and 12 months after cartilage injection (p < 0.005). No major complications were observed after injection. Initial clinical results with intracordal auricular cartilage injection are promising for patients with unilateral vocal fold paralysis. Autologous auricular cartilage can be a safe, effective, and alternative material for vocal fold medialization, and can be a long lasting one.
我们评估了单侧声带麻痹患者声带内注射耳廓软骨的疗效和结果。我们的兴趣源于一项犬模型研究的结果，该研究报告称，声带内自体软骨注射后2年和3年，软骨的组织学特征得以保留。在2002年5月至2010年7月期间，29例因单侧声带麻痹导致呼吸性发声困难的患者接受了声带内耳廓软骨注射。每位受试者均接受术前和术后的感知评估、声学语音分析和频闪喉镜检查。14例患者为男性，平均年龄为52岁。对患者进行了平均257天的跟踪。注射在全身麻醉下经口进行。软骨注射后3个月、6个月和12个月，GRBAS量表的感知评估、抖动、闪烁、噪声与谐波比和最大发声时间的声学参数均有显著改善（p < 0.005）。注射后未观察到重大并发症。声带内注射耳廓软骨的初步临床结果对单侧声带麻痹患者很有前景。自体耳廓软骨可以是一种安全、有效的声带内移替代材料，并且可以持久。
