Zhang Zhefeng, Jin Feng, Sun Liguang, Wu Hao, Chen Bing, Cui Youbin
Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Academy of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Oncol Lett. 2014 May;7(5):1414-1418. doi: 10.3892/ol.2014.1895. Epub 2014 Feb 20.
Inflammatory pseudotumors are rare benign tumors consisting of cellular and stromal elements of a localized reactive process. While inflammatory pseudotumors are commonly detected in the lung and occasionally in other organs, only one case of inflammatory pseudotumor of the thymus has been reported in the literature to date. This report presents a 54-year-old male patient with inflammatory pseudotumor of the thymus accompanied by pulmonary inflammation. The patient presented with chest pain and moderate fever for 12 days. Enhanced computed tomography of the thorax revealed an anterior mediastinal solid and cystic mass, which constricted the left brachiocephalic vein accompanied by bilateral lung inflammation and marginal pleural effusion. The patient underwent a median sternotomy for the surgical removal of the mass. Histologically, the resected mass was composed of necrotic and fibrous tissues and inflammatory infiltrates, and the diagnosis was confirmed as an inflammatory pseudotumor of the thymus. The patient's symptoms were resolved following surgery and the patient remained asymptomatic during the six-month follow-up period. In addition, we reviewed the previous literature and discussed the diagnosis and management of our patient. This report provides further insights into the pathogenesis and underlying mechanisms of inflammatory pseudotumors of the thymus to aid in the diagnosis and development of effective therapies.
炎性假瘤是由局部反应性过程的细胞和间质成分组成的罕见良性肿瘤。虽然炎性假瘤常见于肺部，偶尔也见于其他器官，但迄今为止文献中仅报道过1例胸腺炎性假瘤。本报告介绍了1例54岁男性胸腺炎性假瘤伴肺部炎症患者。该患者出现胸痛和中度发热12天。胸部增强计算机断层扫描显示前纵隔实性和囊性肿块，压迫左头臂静脉，伴有双侧肺部炎症和边缘性胸腔积液。患者接受了正中胸骨切开术以手术切除肿块。组织学检查显示，切除的肿块由坏死组织、纤维组织和炎性浸润组成，确诊为胸腺炎性假瘤。术后患者症状缓解，在6个月的随访期内无症状。此外，我们回顾了既往文献并讨论了该患者的诊断和治疗。本报告为胸腺炎性假瘤的发病机制和潜在机制提供了进一步的见解，有助于诊断和开发有效的治疗方法。
