具有不寻常免疫表型的无症状T细胞大颗粒淋巴细胞白血病。

Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype.

作者信息

Petsa Panagiota K, Karamoutsios Achilleas, Dova Lefkothea, Benetatos Leonidas, Petsiou Asimina, Kolaitis Nikolaos, Georgopoulos Antonis, Vartholomatos Georgios

机构信息

Laboratory of Hematology, Unit of Molecular Biology, University Hospital of Ioannina;

Laboratory of Hematology, University Hospital of Ioannina;

出版信息

Clin Pract. 2012 Jun 27;2(3):e68. doi: 10.4081/cp.2012.e68. eCollection 2012 May 29.

DOI:10.4081/cp.2012.e68

PMID:24765467

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3981314/

Abstract

T-cell large granular lymphocyte (T-LGL) leukemia represents a clonal proliferation of cytotoxic T-cells which etiology has not been entirely elucidated. However, CD4(+), CD4(-), CD8(-), CD4(+), CD8(+) cases have been described. The disease is usually characterized by cytopenias and a modest lymphocytosis. The majority of patients with T-LGL leukemia remains asymptomatic for a long period and will require treatment later during the course of their disease. Hereby we describe a case of T-LGL leukemia diagnosed by flow cytometry, which presented indolent course and required no treatment so far.

摘要

T细胞大颗粒淋巴细胞（T-LGL）白血病是一种细胞毒性T细胞的克隆性增殖疾病，其病因尚未完全阐明。然而，已有CD4(+)、CD4(-)、CD8(-)、CD4(+)、CD8(+)病例的报道。该疾病通常以血细胞减少和轻度淋巴细胞增多为特征。大多数T-LGL白血病患者长期无症状，在疾病过程后期才需要治疗。在此，我们描述一例通过流式细胞术诊断的T-LGL白血病病例，该病例病程缓慢，迄今为止无需治疗。