Parish Tanya
TB Discovery Research, Infectious Disease Research Institute, Seattle, WA 98102, USA.
Chem Biol. 2014 Apr 24;21(4):437-438. doi: 10.1016/j.chembiol.2014.04.002.
Controlled proteolysis is key to bacterial viability. In this issue of Chemistry & Biology, Gavrish and colleagues characterize a natural product, lassomycin, targeting the Mycobacterium tuberculosis caseinolytic (Clp) protease. Unusually, lassomycin activates ClpC1, inducing ATPase activity and decoupling it from proteolysis.
可控蛋白水解是细菌生存能力的关键。在本期《化学生物学》中，加夫里什及其同事对一种靶向结核分枝杆菌酪蛋白水解（Clp）蛋白酶的天然产物——拉索霉素进行了表征。不同寻常的是，拉索霉素激活ClpC1，诱导ATP酶活性并使其与蛋白水解解偶联。
