Zhang Tao, Lu Jian, Zhang Xueqin, Liang Hongwei, Miao Xiaofen, Jiang Jifeng, Ding Ding, Yang Xuefei
Department of Radiology, Third Municipal People's Hospital, Nantong 226006, China.
Department of Radiology, Third Municipal People's Hospital, Nantong 226006, China. Email:
Zhonghua Yi Xue Za Zhi. 2014 Feb 25;94(7):517-20.
To assess the diagnostic value of hepatobiliary phase imaging with GD-EOB-DTPA for hepatocellular carcinomas (HCC) in cirrhosis.
A total of 43 cirrhotic patients with 45 HCC lesions underwent the examinations of T2WI, DWI, T1WI in-phase and opposed-phase and dynamic contrast enhancement and hepatobiliary phase. Two separate analyses of imaging set with and without hepatobiliary phase images were performed. The confidence scores for HCC diagnosis, consistency, area under the receiver operating characteristic (ROC) curve and sensitivity and positive predictive values of two observers were compared.
After adding hepatobiliary phase, there was a significant increase of confidence scores in diagnosing HCC by both observers (P < 0.05) and the consistency of two observers also increased. The area under the ROC curve improved by both observers, but no significant differences were detected (P > 0.05). The sensitivity increased significantly (P < 0.05) and no significant differences were observed for the positive predictive values by both observers (P > 0.05).
Hepatobiliary phase imaging may improve the diagnostic confidence and sensitivity of GD-EOB-DTPA for HCC in cirrhosis.
评估使用钆塞酸二钠（GD-EOB-DTPA）进行肝胆期成像对肝硬化患者肝细胞癌（HCC）的诊断价值。
43例肝硬化合并45个HCC病灶的患者接受了T2加权成像（T2WI）、扩散加权成像（DWI）、同相位和反相位T1加权成像（T1WI）、动态对比增强成像及肝胆期成像检查。对有无肝胆期图像的成像数据集分别进行分析。比较两名观察者对HCC诊断的置信度评分、一致性、受试者操作特征（ROC）曲线下面积、敏感性及阳性预测值。
添加肝胆期图像后，两名观察者对HCC诊断的置信度评分均显著提高（P<0.05），且两名观察者之间的一致性也有所增加。两名观察者的ROC曲线下面积均有所改善，但差异无统计学意义（P>0.05）。敏感性显著提高（P<0.05），两名观察者的阳性预测值差异无统计学意义（P>0.05）。
肝胆期成像可能提高钆塞酸二钠对肝硬化患者HCC的诊断置信度及敏感性。
