Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, Campus Sescelades Marcel lí Domingo, s/n, 43007 Tarragona, Spain.
Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, Campus Sescelades Marcel lí Domingo, s/n, 43007 Tarragona, Spain.
J Chromatogr A. 2014 May 23;1343:55-62. doi: 10.1016/j.chroma.2014.03.068. Epub 2014 Apr 4.
This paper presents eight distinct strong cation-exchange resins, all of which were derived from precursor resins that had been synthesised using either precipitation polymerisation or non-aqueous dispersion polymerisation. The precursor resins were transformed into the corresponding strong cation-exchange resins by hypercrosslinking followed by polymer analogous reactions, to yield materials with high specific surface areas and strong cation-exchange character. These novel resins were then evaluated as strong cation-exchange (SCX) sorbents in the solid-phase extraction (SPE) of a group of drugs from aqueous samples. Following preliminary experiments, the two best-performing resins were then evaluated in solid-phase extraction-liquid chromatography-tandem mass spectrometry (SPE/LC-MS/MS) to determine a group of drugs from sewage samples. In general, use of these sorbents led to excellent recovery values (75-100%) for most of the target drugs and negligible matrix effects (ME) (<20% ion suppression/enhancement of the analyte signal), when 50mL and 25mL of effluent and influent sewage water samples, respectively, were percolated through the resins. Finally, a validated method based on SPE/LC-MS/MS was used to quantify the target drugs present in different sewage samples.
本文介绍了 8 种不同的强阳离子交换树脂，它们均源自使用沉淀聚合或非水相分散聚合合成的前体树脂。通过超交联和聚合物类似反应，将前体树脂转化为相应的强阳离子交换树脂，得到具有高比表面积和强阳离子交换特性的材料。然后，将这些新型树脂作为强阳离子交换（SCX）吸附剂，用于从水样中萃取一组药物。在初步实验后，对两种性能最佳的树脂进行了固相萃取-液相色谱-串联质谱（SPE/LC-MS/MS）评估，以从污水样品中测定一组药物。一般来说，当分别用 50mL 和 25mL 出水和进水污水样品通过树脂时，这些吸附剂对大多数目标药物的回收率非常高（75-100%），且基质效应（ME）可忽略不计（<20%的分析物信号抑制/增强）。最后，基于 SPE/LC-MS/MS 的验证方法用于定量不同污水样品中存在的目标药物。
