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SLC1A1 基因中的单核苷酸多态性与强迫症发病年龄有关。

A single nucleotide polymorphism in SLC1A1 gene is associated with age of onset of obsessive-compulsive disorder.

机构信息

Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy.

Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy.

出版信息

Eur Psychiatry. 2014 Jun;29(5):301-3. doi: 10.1016/j.eurpsy.2014.02.006. Epub 2014 Apr 24.

DOI:10.1016/j.eurpsy.2014.02.006
PMID:24768158
Abstract

Different genetic polymorphisms in the SLC1A1 have been shown to be associated with obsessive-compulsive disorder. Rs301430 is a T/C functional polymorphism affecting the gene expression and extrasynaptic glutamate concentration.We observed that Rs301430 influence age at onset in obsessive-compulsive disorder.

摘要

已有研究表明，SLC1A1 中的不同基因多态性与强迫症有关。rs301430 是一个影响基因表达和 extrasynaptic 谷氨酸浓度的 T/C 功能多态性。我们观察到 rs301430 影响强迫症的发病年龄。

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