Roversi R, Rossi C, Ricci S, Galaverni M C, Teodorani A, Gambari P, Gardini G, Boriani S, Corinaldesi A
Istituto di Radiologia, Università, Bologna.
Radiol Med. 1989 Jul-Aug;78(1-2):79-88.
The authors report their 4-year (1984-1988) experience with TCE in the treatment of primary sacral benign/malignant and vascular bone tumors, after similar preliminary studies on aneurysmal bone cysts. Eleven patients were treated, for a total of 21 procedures: in 85% of the eight cases of palliative embolization, multiple instrumental approaches were needed for late revascularization, up to four consecutive embolizations in the same patients. Severe complications were observed in 19% of the procedures, due to arterial catheterization and/or instrumental maneuvers, but in none of them was surgery required. Technical results--i.e. devascularization of the mass--were optimal/suboptimal in all cases at the end of multiple procedures in the same patient: in 7/8 patients treated for palliation, however, the treatment was repeated, the late venous DSA angiographic control showing recanalization of the great vessels surrounding the lesion and/or revascularization through collateral channels. The analysis of morphological and clinical results (with reference to pain relief, dimension of the mass, and calcification at CT follow up) showed a complete pain relief in 100% of the patients treated preoperatively for palliation. The dimension of the mass was reduced in 12.5% of the cases treated for palliation, and recalcification was demonstrated on CT in 12.5% of cases. In 25.5% the mass had increased in size and in 62.5% its dimensions were unchanged. Effective pain relief was always obtained in the cases treated preoperatively. Thus, in our experience TCE of expansive lesions of the sacral bone can be considered as an effective therapeutical choice, with special reference to pain relief, for use in all inoperable cases, and as a preoperative treatment to minimize blood loss at surgery. Still, embolization materials are not completely satisfying: many of them are expensive, difficult to use and cannot be trusted to permanently occlude the vessels, which forces to intervene more than once to obtain optimal clinicomorphological results. As for malignant lesions, chemo-embolization with cytostatic substances should be used to improve the efficacy of the method. However, even through such negative judgements can be expressed on TCE, both technical and clinical results have been, in our experience, quite satisfactory, which calls for optimization of the methodology.
作者报告了他们在对动脉瘤样骨囊肿进行类似初步研究后,于1984年至1988年期间使用经导管动脉栓塞术(TCE)治疗原发性骶骨良性/恶性及血管性骨肿瘤的4年经验。共治疗了11例患者,总计进行了21次操作:在8例姑息性栓塞病例中的85%,由于后期再血管化需要多种器械方法,同一患者最多连续进行4次栓塞。19%的操作出现了严重并发症,原因是动脉插管和/或器械操作,但均无需手术处理。在同一患者多次操作结束时,技术结果(即肿块去血管化)在所有病例中均为最佳/次佳:然而,在7/8例接受姑息治疗的患者中,治疗进行了重复,后期静脉数字减影血管造影(DSA)控制显示病变周围大血管再通和/或通过侧支通道再血管化。对形态学和临床结果(参考疼痛缓解、肿块大小及CT随访时的钙化情况)的分析显示,术前接受姑息治疗的患者100%疼痛完全缓解。接受姑息治疗的病例中12.5%肿块大小缩小,CT显示12.5%的病例有重新钙化。25.5%的病例肿块增大,62.5%的病例肿块大小无变化。术前治疗的病例总能有效缓解疼痛。因此,根据我们的经验,骶骨膨胀性病变的TCE可被视为一种有效的治疗选择,特别是在缓解疼痛方面,适用于所有无法手术的病例,并可作为术前治疗以减少手术中的失血。不过,栓塞材料仍不尽人意:许多材料昂贵、使用困难且不能确保永久闭塞血管,这就需要不止一次干预以获得最佳临床形态学结果。对于恶性病变,应使用含细胞毒性物质的化疗栓塞来提高该方法的疗效。然而,尽管对TCE可做出这样负面的评价,但根据我们的经验,技术和临床结果都相当令人满意,这就需要对方法进行优化。