Pfeiffer-Linn C, Glantz R M
Department of Biology, Rice University, Houston TX 77251.
Science. 1989 Sep 15;245(4923):1249-51. doi: 10.1126/science.2476848.
A central principle of neural integration is that excitatory and inhibitory neurotransmitters effect the opening of distinct classes of membrane ionic channels and that integration consists of the summation of the opposing ionic currents on the postsynaptic membrane. In tangential cells of crayfish optic lobes, a hyperpolarizing, biphasic synaptic potential is produced by the concurrent action of acetylcholine and gamma aminobutyric acid (GABA). Acetylcholine hyperpolarizes the cell and increases chlorine conductance. GABA depolarizes the cell by closing some of the same chloride channels. Therefore, in this case integration is achieved by the antagonistic actions of two transmitters on the same ionic channel.
神经整合的一个核心原则是，兴奋性和抑制性神经递质会影响不同类型的膜离子通道的开放，并且整合过程包括突触后膜上相反离子电流的总和。在小龙虾视叶的切向细胞中，乙酰胆碱和γ-氨基丁酸（GABA）的共同作用会产生一种超极化的双相突触电位。乙酰胆碱使细胞超极化并增加氯电导。GABA通过关闭一些相同的氯离子通道使细胞去极化。因此，在这种情况下，整合是通过两种递质对同一离子通道的拮抗作用来实现的。
