Department of Fish Physiology and Biotechnology, Instituto de Acuicultura de Torre de la Sal, Consejo Superior de Investigaciones Científicas (IATS-CSIC), Ribera de Cabanes, Castellón, Spain.
Department of Fish Physiology and Biotechnology, Instituto de Acuicultura de Torre de la Sal, Consejo Superior de Investigaciones Científicas (IATS-CSIC), Ribera de Cabanes, Castellón, Spain.
Gen Comp Endocrinol. 2014 Dec 1;209:3-10. doi: 10.1016/j.ygcen.2014.04.005. Epub 2014 Apr 21.
The melanocortin system is one of the most complex of the hormonal systems. It involves different agonists encoded in the multiplex precursor proopiomelanocortin (POMC) or in different genes as β-defensins, endogenous antagonist, like agouti-signalling protein (ASIP) or agouti-related protein (AGRP), and five different melanocortin receptors (MCRs). Rounds of whole genome duplication events have preceded the functional and molecular diversification of the family in addition some co-evolutionary and tandem duplication processes have been proposed. The evolutionary patterns of the different partners are controversial and different hypotheses have emerged from a study of the sequenced genomes. In this review, we summarize the different evolutionary hypotheses proposed for the different melanocortin partners.
黑素皮质素系统是激素系统中最复杂的系统之一。它涉及不同的激动剂，这些激动剂编码在多聚体前体 proopiomelanocortin（POMC）中，或者编码在不同的基因中，如β-防御素、内源性拮抗剂，如刺鼠相关蛋白（ASIP）或刺鼠相关蛋白（AGRP），以及五个不同的黑素皮质素受体（MCRs）。除了一些共同进化和串联重复过程外，全基因组重复事件的出现导致了该家族的功能和分子多样化。不同伴侣的进化模式存在争议，不同的假设已经从对已测序基因组的研究中出现。在这篇综述中，我们总结了为不同的黑素皮质素伴侣提出的不同进化假设。
