硫酸化非抗凝低分子量肝素抑制胰腺癌。
Suppression of pancreatic cancer by sulfated non-anticoagulant low molecular weight heparin.
机构信息
The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA.
The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA; Department of Physiology, Veterinary Medicine Faculty, Uludag University, Gorukle, Bursa, Turkey.
出版信息
Cancer Lett. 2014 Aug 1;350(1-2):25-33. doi: 10.1016/j.canlet.2014.04.016. Epub 2014 Apr 24.
Sulfated non-anticoagulant heparins (S-NACHs) might be preferred for potential clinical use in cancer patients without affecting hemostasis as compared to low molecular weight heparins (LMWHs). We investigated anti-tumor effects, anti-angiogenesis effects, and mechanisms of S-NACH in a mouse model of pancreatic cancer as compared to the LMWH tinzaparin. S-NACH or tinzaparin with or without gemcitabine were administered, and tumor luminescent signal intensity, tumor weight, and histopathology were assessed at the termination of the study. S-NACH and LMWH efficiently inhibited tumor growth and metastasis, without any observed bleeding events with S-NACH as compared to tinzaparin. S-NACH distinctly increased tumor necrosis and enhanced gemcitabine response in the mouse pancreatic cancer models. These data suggest the potential implication of S-NACH as a neoadjuvant in pancreatic cancer.
硫酸化非抗凝肝素（S-NACH）可能比低分子量肝素（LMWH）更适合在癌症患者中用于潜在的临床应用，而不会影响止血。我们研究了 S-NACH 与 LMWH 亭扎肝素相比在胰腺癌小鼠模型中的抗肿瘤作用、抗血管生成作用和机制。在研究结束时，评估了 S-NACH 或亭扎肝素加或不加吉西他滨的肿瘤发光信号强度、肿瘤重量和组织病理学。S-NACH 和 LMWH 有效地抑制了肿瘤生长和转移，与亭扎肝素相比，S-NACH 没有观察到任何出血事件。S-NACH 明显增加了小鼠胰腺癌模型中的肿瘤坏死，并增强了吉西他滨的反应。这些数据表明 S-NACH 作为胰腺癌新辅助治疗的潜在意义。
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