对四种新型设计药物5-氯-NNEI、NNEI吲唑类似物、α-PHPP和α-POP以及非法产品中11种新发现的设计药物的特性分析。
Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, α-PHPP and α-POP, with 11 newly distributed designer drugs in illegal products.
作者信息
Uchiyama Nahoko, Matsuda Satoru, Kawamura Maiko, Shimokawa Yoshihiko, Kikura-Hanajiri Ruri, Aritake Kosuke, Urade Yoshihiro, Goda Yukihiro
机构信息
National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
出版信息
Forensic Sci Int. 2014 Oct;243:1-13. doi: 10.1016/j.forsciint.2014.03.013. Epub 2014 Mar 27.
Our continuous survey of illegal products in Japan revealed the new distribution of 15 designer drugs. We identified four synthetic cannabinoids, i.e., NNEI (1), 5-fluoro-NNEI (2), 5-chloro-NNEI (3) and NNEI indazole analog (4), and seven cathinone derivatives, i.e., MPHP (5), α-PHPP (6), α-POP (7), 3,4-dimethoxy-α-PVP (8), 4-fluoro-α-PVP (9), α-ethylaminopentiophenone (10) and N-ethyl-4-methylpentedrone (11). We also determined LY-2183240 (12) and its 2'-isomer (13), which were reported to inhibit endocannabinoid uptake, a methylphenidate analog, 3,4-dichloromethylphenidate (14), and an MDA analog, 5-APDB (15). No chemical and pharmaceutical data for compounds 3, 4, 6 and 7 had been reported, making this the first report on these compounds.
我们对日本非法产品的持续调查揭示了15种新型毒品的新分布情况。我们鉴定出4种合成大麻素，即NNEI（1）、5-氟-NNEI（2）、5-氯-NNEI（3）和NNEI吲唑类似物（4），以及7种卡西酮衍生物，即MPHP（5）、α-PHPP（6）、α-POP（7）、3,4-二甲氧基-α-PVP（8）、4-氟-α-PVP（9）、α-乙基氨基戊苯酮（10）和N-乙基-4-甲基戊二酮（11）。我们还确定了LY-2183240（12）及其2'-异构体（13），据报道它们可抑制内源性大麻素摄取，一种哌醋甲酯类似物3,4-二氯甲基哌醋甲酯（14），以及一种MDA类似物5-APDB（15）。此前没有关于化合物3、4、6和7的化学和药学数据报道，因此这是关于这些化合物的首次报告。
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