人类与言语和阅读相关的基因在狨猴大脑中表现出部分重叠的表达模式。
Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain.
作者信息
Kato Masaki, Okanoya Kazuo, Koike Taku, Sasaki Erika, Okano Hideyuki, Watanabe Shigeru, Iriki Atsushi
机构信息
Laboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Laboratory for Biolinguistics, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Center for Advanced Research on Logic and Sensibility (CARLS), Keio University, 2-15-45 Mita, Minato-ku, Tokyo 108-8345, Japan.
Laboratory for Biolinguistics, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
出版信息
Brain Lang. 2014 Jun;133:26-38. doi: 10.1016/j.bandl.2014.03.007. Epub 2014 Apr 24.
Language is a characteristic feature of human communication. Several familial language impairments have been identified, and candidate genes for language impairments already isolated. Studies comparing expression patterns of these genes in human brain are necessary to further understanding of these genes. However, it is difficult to examine gene expression in human brain. In this study, we used a non-human primate (common marmoset; Callithrix jacchus) as a biological model of the human brain to investigate expression patterns of human speech- and reading-related genes. Expression patterns of speech disorder- (FoxP2, FoxP1, CNTNAP2, and CMIP) and dyslexia- (ROBO1, DCDC2, and KIAA0319) related genes were analyzed. We found the genes displayed overlapping expression patterns in the ocular, auditory, and motor systems. Our results enhance understanding of the molecular mechanisms underlying language impairments.
语言是人类交流的一个显著特征。已经确定了几种家族性语言障碍，并且已经分离出语言障碍的候选基因。比较这些基因在人类大脑中的表达模式的研究对于进一步了解这些基因是必要的。然而，在人类大脑中检测基因表达是困难的。在本研究中，我们使用非人类灵长类动物（普通狨猴；绢毛猴）作为人类大脑的生物学模型，以研究人类言语和阅读相关基因的表达模式。分析了言语障碍相关基因（FoxP2、FoxP1、CNTNAP2和CMIP）和阅读障碍相关基因（ROBO1、DCDC2和KIAA0319）的表达模式。我们发现这些基因在视觉、听觉和运动系统中表现出重叠的表达模式。我们的结果增强了对语言障碍潜在分子机制的理解。
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