Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Department of Rehabilitation, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
Neurosci Lett. 2014 Jun 6;570:108-13. doi: 10.1016/j.neulet.2014.04.021. Epub 2014 Apr 24.
To estimate the associations between vitamin D status and multiple sclerosis (MS). We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to February, 2014 using the following keywords: 'vitamin D' or '25(OH)D' and 'status' or 'deficiency' or 'insufficiency' and 'multiple sclerosis'. A systematic review and meta-analysis were conducted on observational studies that reported the association between blood vitamin D levels and MS. Eleven studies met the inclusion criteria. 1007 patients and 829 controls were included. Results of our meta-analysis show that MS patients had lower mean levels of 25-hydroxyvitamin D [25(OH)D] than healthy controls (weighted mean difference[MD], -14.52, 95% confidence interval [CI], -23.83 to -5.22). There were statistically significant heterogeneity (P<0.00001; I(2)=92%). The significant heterogeneity may be due to the differences in ethnicity, country, season of blood sampling and age of the participants studied. To sum up, low vitamin D levels are associated with an increased risk of MS.
评估维生素 D 状态与多发性硬化症（MS）之间的关联。我们在 PubMed、EMBASE 和 Cochrane Library 电子数据库中搜索了人类文献，检索日期截至 2014 年 2 月，使用了以下关键词：“vitamin D”或“25(OH)D”和“status”或“deficiency”或“insufficiency”和“multiple sclerosis”。对报告血液维生素 D 水平与 MS 之间关联的观察性研究进行了系统评价和荟萃分析。符合纳入标准的有 11 项研究。纳入了 1007 例患者和 829 例对照。荟萃分析结果表明，MS 患者的 25-羟维生素 D [25(OH)D]平均水平低于健康对照者（加权均数差[MD]，-14.52，95%置信区间[CI]，-23.83 至-5.22）。存在统计学显著异质性（P<0.00001；I(2)=92%）。显著的异质性可能是由于种族、国家、采血季节和研究参与者年龄的差异所致。总之，低维生素 D 水平与 MS 风险增加相关。
