Urano Tomohiko
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Japan.
Clin Calcium. 2014 May;24(5):685-93.
Osteoporosis is a common skeletal disease characterized by low bone mineral density (BMD) and microarchitectural deterioration of bone tissue. Osteoporosis increases susceptibility to fracture. Over the last 10 years, genome-wide association studies (GWAS) have identified the single-nucleotide polymorphisms (SNPs) associated with low BMD, osteoporosis and osteoporotic fractures. These SNPs were mapped close to or within the genes, such as Wnt- and RANKL-related genes. In the future, molecular epidemiology of osteoporosis may provide novel candidates for therapeutic targets.
骨质疏松症是一种常见的骨骼疾病，其特征为骨矿物质密度（BMD）低以及骨组织微结构恶化。骨质疏松症会增加骨折易感性。在过去10年中，全基因组关联研究（GWAS）已鉴定出与低骨密度、骨质疏松症和骨质疏松性骨折相关的单核苷酸多态性（SNP）。这些SNP被定位在靠近基因或基因内部，如与Wnt和RANKL相关的基因。未来，骨质疏松症的分子流行病学可能会为治疗靶点提供新的候选物。
