[顺铂-磷脂酰胆碱-碘油（CPL）混悬液化疗用于不可切除肝细胞癌]
[Chemotherapy with Cisplatin-Phosphatidyl-choline-Lipiodol (CPL) suspension in unresectable hepatocellular carcinoma].
作者信息
Aoki Y, Hirai K, Yamashita K, Noguchi H, Sakai T, Majima Y, Tanikawa K, Inoue H, Okano Y, Hitoshi T
机构信息
Second Dept. of Medicine, Kurume University School of Medicine.
出版信息
Gan To Kagaku Ryoho. 1989 Aug;16(8 Pt 2):3066-9.
Twenty-seven patients with unresectable hepatocellular carcinoma (HCC) were treated with Cisplatin-Phosphatidyl-choline-Lipiodol (CPL) suspension. PR was obtained in two of ten cases (20%) by one shot therapy. AFP decreased in 9 of 10 patients by one shot therapy with a 62.1% rate of decrease. In all of 13 patients by TAE, AFP decreased and the rate of decrease was 64.8%. The concentration of CDDP in the peripheral venous blood was lower and continued longer than that of CDDP on the market. Nausea, vomiting and fever were noted in most cases as adverse effects, but they were slight. These results suggest that CPL agents were very chemotherapeutic for unresectable HCC.
27例无法切除的肝细胞癌（HCC）患者接受了顺铂-磷脂酰胆碱-碘油（CPL）混悬液治疗。10例患者中2例（20%）单次治疗后获得部分缓解（PR）。10例患者中9例单次治疗后甲胎蛋白（AFP）下降，下降率为62.1%。在接受经动脉栓塞化疗（TAE）的13例患者中，AFP均下降，下降率为64.8%。外周静脉血中顺铂（CDDP）的浓度低于市售CDDP，且持续时间更长。多数病例出现恶心、呕吐和发热等不良反应，但症状较轻。这些结果表明CPL制剂对无法切除的HCC具有很好的化疗效果。
Zotero 插件