对维拉帕米系列中钙通道激活剂的研究。
A search for calcium-channel activators in the verapamil series.
作者信息
Romanelli M N, Gualtieri F, Mannhold R, Chiarini A
机构信息
Dipartimento di Scienze Farmaceutiche, Università di Firenze, Italy.
出版信息
Farmaco. 1989 May;44(5):449-64. doi: 10.1002/chin.198952109.
PMID:2476997
Abstract
A new series of phenylalkylamines related to Verapamil have been synthesized and their Ca2+-modulating activity on rabbit aorta and on guinea-pig heart were evaluated. The compounds display only a moderate Ca2+-antagonistic activity; none of them showed any Ca2+-agonistic effect.
摘要
已经合成了一系列与维拉帕米相关的新型苯烷基胺，并评估了它们对兔主动脉和豚鼠心脏的钙调节活性。这些化合物仅表现出中等程度的钙拮抗活性；它们中没有一个显示出任何钙激动作用。
Zotero 插件