Wang Xiao-fei, Feng Yun, Chen Ying, Gao Bei Li, Han Bao-hui
1] Department of pulmonary Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025, Shanghai, China [2] Department of pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, 200030, Shanghai, China [3].
1] Department of pulmonary Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025, Shanghai, China [2].
Sci Rep. 2014 Apr 28;4:4813. doi: 10.1038/srep04813.
Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life and is one of the reasons for the discontinuation of treatment. Olanzapine is known as an atypical antipsychotic agent, but it has been reported to be effective in treating refractory CINV due to its broad and potent inhibitory activity at multiple receptors involved in the nausea and vomiting pathways. This study was conducted to assess the efficacy of olanzapine for the prevention of CINV after moderately or highly emetogenic chemotherapy. After a search of Medline (Ovid), PubMed, CNKI, Wanfang and Weipu from 1990 to October 2013, all randomised controlled trials of olanzapine for the prevention of CINV were included in this study. The meta-analysis was performed using RevMan 5.0.19 software. 6 studies involving 726 total patients were included, of which 441 were Chinese oncology patients. We found that for both general populations and Chinese populations, antiemetic regimens including olanzapine are more effective at reducing CINV than regimens that do not include olanzapine, especially in the delayed phase of CINV.
化疗引起的恶心和呕吐（CINV）与生活质量的显著下降相关，并且是导致治疗中断的原因之一。奥氮平是一种非典型抗精神病药物，但据报道，由于其对恶心和呕吐途径中多个受体具有广泛而强效的抑制活性，它在治疗难治性CINV方面有效。本研究旨在评估奥氮平在预防中度或高度致吐性化疗后CINV的疗效。在检索1990年至2013年10月的Medline（Ovid）、PubMed、中国知网、万方和维普后，本研究纳入了所有奥氮平预防CINV的随机对照试验。使用RevMan 5.0.19软件进行荟萃分析。纳入了6项研究，共726例患者，其中441例为中国肿瘤患者。我们发现，对于一般人群和中国人群，包含奥氮平的止吐方案在减少CINV方面比不包含奥氮平的方案更有效，尤其是在CINV的延迟期。
