Clanet M, Blancher A, Calvas P, Rascol O
Service de Neurologie, CHU Purpan, Toulouse, France.
Biomed Pharmacother. 1989;43(5):355-60. doi: 10.1016/0753-3322(89)90061-9.
Interferons (IFNs) are a family of proteins with antiviral, antitumoral and immunomodulating properties. Multiple Sclerosis (MS) is a CNS disease in which the immune reaction (IR) is the cause of the inflammatory demyelinating lesions. IFNs have been demonstrated in active lesions. The location of IFN gamma on astrocytes suggests an enhancing activity on IR by inducing Ia antigen expression on these cells. In contrast, IFN alpha/beta located on microglial cells and astrocytes might limit the growing lesion. MS patients frequently present a defective response of NK cell activity and an abnormally low production of IFNs reflecting immune dysregulation. The therapeutic trials available to date are discussed: IFN gamma possesses a severe deleterious effect but IFN alpha/beta are still under consideration due to a possible beneficial activity.
干扰素（IFNs）是一类具有抗病毒、抗肿瘤和免疫调节特性的蛋白质。多发性硬化症（MS）是一种中枢神经系统疾病，其中免疫反应（IR）是炎症性脱髓鞘病变的病因。在活跃病变中已证实存在干扰素。γ干扰素在星形胶质细胞上的定位表明，通过诱导这些细胞上Ia抗原的表达，对免疫反应具有增强活性。相比之下，位于小胶质细胞和星形胶质细胞上的α/β干扰素可能会限制病变的发展。MS患者经常出现自然杀伤细胞活性反应缺陷以及反映免疫失调的干扰素产生异常低下的情况。本文讨论了迄今为止可用的治疗试验：γ干扰素具有严重的有害作用，但α/β干扰素由于可能具有有益活性仍在考虑之中。
